Senior Scientist, Experimental Genomics & Off-Target Biology at Beam Therapeutics
Cambridge, United States
Job Descrption
Position Overview
Beam is seeking a talented and dynamic Senior Scientist to join our growing Experimental Genomics & Off-Target Biology team at our state-of-the-art lab and office facilities in Cambridge, MA. This Senior Scientist will be responsible for tackling complex technical problems related to off-target editing for therapeutic program advancement and platform development using published, custom, and novel NGS-based assays. This new role will be embedded within a team of stellar experimental and computational biologists. Candidates for this role should excel at working both independently and in service of highly cross-functional, interdisciplinary research projects. The successful applicant will have a strong scientific background in genomics assays and/or gene editing, a track record of excellence in scientific collaboration and communication, and a passion for driving scientific innovation at the forefront of gene editing. This is an on-site position located in Cambridge, MA.
Responsibilities:
Lead the design, development, and execution of NGS-based assays and experiments to assess the activity and specificity of base editors, aimed at addressing fundamental questions related to off-target biology.
Provide creative, efficient, and strategic experimental solutions at all stages of the discovery and therapeutic development process.
Engage in impactful research projects to strengthen Beam’s off-target biology platform and streamline our therapeutic pipeline.
Collaborate and coordinate with other teams and individuals across Beam’s integrated research platform and beyond, including other experimental biologists, computational biologists, therapeutic areas, nonclinical development, and others.
Act as an internal subject-matter expert in topics related to genomics and NGS assays.
Execute IND-enabling off-target studies in support of therapeutic programs.
Contribute to regulatory reports and scientific publications.
Lead by example in scientific excellence and mentorship, fostering a culture of growth and collaboration with team members.
Maintain detailed documentation of experiments in electronic lab notebooks.
Qualifications:
PhD in molecular biology, functional genomics, bioengineering, or other relevant field of biology with additional 4-6 years of relevant experience; or a Bachelor’s/Master’s degree with 12-15 years of relevant experience.
Industry experience is preferred, especially in fast-paced, matrixed environments.
Extensive first-hand, bench-science experience and skills, especially with diverse NGS-enabled methods, and ideally including assay development and troubleshooting.